Top 10 Supplements for Histamine Intolerance
Want to escape the histamine intolerance trap, and figure out which supplements have the most potential? If the answer is yes, then this article could change your life. The reason is, it is written by someone who actually overcame histamine intolerance, and while doing so, discovered the supplements needed to escape this terrifying situation.
In this article, I will list many of the supplements I used to overcame mast cell activation and histamine intolerance. Keep in mind, this list is a product of 19+ years of research, and endless trial and error. Over $200,000 was spent on ineffective supplements, which in many cases made me even worse. Refer below for details:
TOP 10 Supplements for Histamine Intolerance
1. Chelated Magnesium Glycinate – major cofactor in DAO enzyme production (1), reduces effect of stress on the body (2), increases GABA levels (3), relaxes muscles, increases frequency of bowel movements (4), modulates bifidobacterium growth (5), cofactor for 300+ enzymatic systems (6), reduces anxiety (7), normalizes gene expressions (8)
2. Bifidobacterium – modulates gut-brain inflammatory signaling (9), produces SCFA’s which reduce inflammation systemically (10), removes harmful pathogens via competitive exclusion (11), alters microbiome and regulatory t cells in host favor (12), helps to combat candida overgrowth (13) – SEEKING HEALTH BRAND
3. Vitamin K2/D3– suppresses IgE dependent mast cell activation (14), required for stabilization of mast cells (15), necessary for proper mineral absorption in the gut (16), improves sleep (17), modulating your genetic expressions (18), helps calcium exit blood which decreases mast cell activation frequency (19) – ZHOU NUTRITION BRAND
4. L-Glutamine Powder– precursor for GABA (20), indirectly reduces histamine effect on brain, most abundant amino acid in the body, helps the intestinal lining repair itself (21), improves and modulates immune function (22), improves sleep by increasing GABA, modulates mast cells response by increasing GABA – AJIPURE BRAND
5. Apigenin– modulates mast cells by competing with estradiol (23), improves depressive like behaviors (24), reduces neurological inflammation (25), modulates GABA levels in brain (26), indirectly reduces histamine, feeds good bacteria in gut and helps fat breakdown (27), inhibits quorum sensing of pathogens which reduces their virulence (28), blocks activation of NF-KB pathway (29), has 81 hour half-life!!!!! – SWANSON BRAND
6. Bee Propolis- has anti-allergy properties (30), controls mast cell degranulation (31), suppress basophil activation and intestinal allergic inflammation (32), antibacterial (33), effective against parasites (34) – ECO BEE FARMS BRAND
7. Chrysin– modulates mast cell reactivity (35), provides antioxidant support, attenuates allergic responses and suppresses allergy related inflammation (36), improves stress response, increases stamina, prohibits viruses from replicating (37), anti-protozoan (38), helps to normalize gene expression and novel HDAC inhibitor (39) – SWANSON BRAND
8. Raw Bovine Colostrum- modulates mast cells by preventing IgE allergy response (40) increases killer cell activity, heals intestinal lining, provides unique nutrition in simplest form possible (41), contains lactoferrin which impairs bacterial infections (42), has strong anti-candida properties (43), improves bowel function, balances blood sugar – FIND AT LOCAL RAW MILK FARMERS
9. Broken Cell Wall Chlorella– increases PH which can calm down mast cells (44), binds to various toxic substances that aggravate immune system and impair detoxification pathways, chelates heavy metals (45), contains all essential amino acids and highest amount of chlorophyll in any plant – FRESH THYME BRAND
10. Beta-Carotene/Carotenoids – Inhibits mast cells from degranulating (45), improves inflammation systemically and scavenges ROS (46), improves blood sugar stability (47), boost immune function against viruses (48), neutralizes harmful free radicals by binding to them, strengthens intestinal barrier and reduces colonic inflammation (49), useful against neurodegenerative disease, can modulate immune response via actions on acetylcholinesterase (50) and cholinergic pathway – SOLARAY PLANT SOURCED BRAND
NOTE: Brands do matter! I do not trust anything but these products mentioned because these are what worked for me, and has worked for my clients.
Key Points to Remember
All Supplements MUST Reduce Histamine Levels or Else
Any supplement that is NOT listed above should be checked to determine their effect on histamine and the mast cells. In my opinion, if you can’t find a study showing it decreases histamine or modulates mast cells, then it is a RISK. The last thing you need to do is trip your mast cells/immune system by taking a supplement that actually aggravates it.
Remember, when you healing your immune system, it’s kind of like “letting the scab heal”. To win this battle, you must recondition the mast cells/immune system so they learn to expect a low stress environment. Then they will secrete primarily anti-inflammatory chemicals, instead of inflammatory ones.
Don’t Cheat on the Low Histamine Diet – Period
Keep in mind, these supplements are far more effective when following a low histamine diet. Simply put, the less histamine you are exposing yourself to, the faster you will progress. If you trip the mast cells with some food with induces histamine secretion/mast cell activation, you are in essence “picking the scab”. Remember, your immune system must be conditioned into being calm via your lifestyle, diet, schedule, and supplementation. At this point, the enemy is no longer histamine, it’s “excessiveness”. Just remember, moderation in all things healthful, avoidance of all things that are not.
Plant/Naturally Derived Supplements are ALWAYS the Best
REMEMBER, plant based supplements are ALWAYS preferred. When dealing with histamine intolerance, synthetic supplements can turn into irritants within weeks, if not days. Keep in mind, you must find your “sweet spot” for each of these supplements. Your success will depend on your adherence to the low histamine diet, the level of stress in your life, and your supplement plan.
Questions – Histamine Intolerance Supplements
Which of the histamine intolerance supplements are necessary?
All of these played an important part in my recovery from histamine intolerance and mast cell activation. Their importance will be dependent upon how deficient you are and other factors. When I work with clients, I implement them at different stages depending on the situation so don’t just try this at home and expect it to pan out perfectly. You NEED help from someone who HAS BEEN THROUGH IT already.
Does the brand of the supplement really matter when fighting histamine intolerance?
YES!!!!! The brand is just as critical as any step in this process. The bioavailability is completely different in one versus another, and with those who are chronically ill, this is even more important.
How will I feel after starting these supplements?
In my experience, if you start the low histamine diet, and the supplements at the same time, you should notice gradual relief over the first 3-5 days. This tension will dissolve slowly into relaxation. At that point, the GABA increases, and your histamine levels start to crash. Typically, you get 2-3 days of DEEP SLEEP after the histamine crash occurs.
Once you wake up from your slumber, your body starts to gain more energy day by day. Within a week, you notice you feel calmer and have more stamina than you did before starting. This is the pattern I followed, along with nearly all of my clients. From beginning to end it only takes 10-15 days (IF DIET IS FOLLOWED 100%) to escape histamine excess.
What is key to success for those battling histamine intolerance?
Identifying ALL hidden triggers in your environment, and then removing them at the same time you start the supplements/diet. DO NOT ADD ANYTHING SUPPLEMENT WISE BEYOND WHAT WAS DISCUSSED ABOVE. Do not cheat for weeks, if not months on low histamine diet, and ROTATE ALL FOODS.
Keep in mind, histamine inducing foods/activities/substances are deeply woven into your daily life. In short, It will not be easy to give these things up, trust me. Either take this seriously and avoid ALL sensitivities, or you’ll be caught in a never ending cycle of symptoms. Do what you know is right, give your immune system 3-4 months without ANY reactions, and then try to live life “how you want to”.
How do you know these supplements work for histamine intolerance?
I overcame histamine intolerance using these strategies and supplements. Furthermore, I even took these supplements after creating a histamine reaction intentionally. This allowed me to determine if they would stop the current reaction from getting worse, or they would make it worse. In addition, all of the supplements listed showed the ability to modulate mast cells and reduce histamine in the 50 studies I linked above. Lastly, this has also worked with my clients, friends, and family.
How can I identify my HIDDEN food sensitivities that are causing histamine issues?
You MUST follow a strict BLAND low histamine diet for 10 days AT LEAST, and then you reintroduce 1 new food every 3 days. If you notice ANY changes in energy/emotion/sleep/allergies/hyperactivity/past symptoms, then you remove that food from your diet. Please keep in mind, the histamine high that comes with some foods can be EASILY misinterpreted. Also, if possible, wear a watch that measures heart beat. If your heart raises 10+ beats per minute within 45 minutes of eating, you may have a food sensitivity.
Common histamine reaction symptoms are red skin, dry skin, itchiness/tingle on skin, mind racing. obsessive thoughts, energy spikes/crashes, brain fog, slow bowel movements, dark feeling comes and goes, slight weakness in muscles, pressure in face/forehead/eyes area, tired shortly after eating, temporary urge to urinate, desire to consume A LOT more food fast, sleep interruptions, touching face more often, etc.
Summary – Top Histamine Reducing Supplements
As you can see, these supplements have unique properties that can reduce histamine, modulate mast cells, fight infection, and even prevent inflammatory signaling in the body. The best part is, while healing histamine intolerance, you also are replacing deficiencies you’ve had for years. This means you can feel better than you ever have once the symptoms we call “histamine intolerance” have disappeared.
In summary, I hope this list is as beneficial to you as I expect it to be. Keep in mind, it took years of research, plenty of money, and endless trial and error to finally discover these hidden gems. The fact is, I have seen these supplements work for myself, my family, and my clients. On top of that, they are backed by far more studies than the 50+ I listed in this article.
What does this all mean for you? Well, I believe with a little help, it means your chances of success are excellent.
If you have any questions, please get in touch. Thanks for reading, and happy healing everyone!
Matt Sikora
EndSickness.org
Phone: (734) 846-8619
Email: endsickness@gmail.com
